Skip to main content

Ok, this is a super geeky science article, but also very fascinating! 🤣

First, a personal story might help this study seem more relevant to your own life. 

I had been drinking ASEA for about three weeks and noticed some positive changes—better sleep; less cramping at night, and no cramping on long ocean swims. I headed out on my usual walk with a friend around Diamond Head (which is a hilly 4.2 mile loop), enough for the day’s exercise. I ran into another friend after finishing and she asked if I wanted to go around with her. I felt spunky so I said yes! 

silhouette of boy running in body of water during sunset

We ran/walked and I finished the morning with 10 miles of hilly running and walking with friends. I hadn’t done that much distance in one day since retiring from racing triathlons in 2000, 17 years earlier. That blew my mind! I’m a life-long athlete and to have that major shift in energy and endurance at 58 years old was a surprise…a good one!

AND it felt like I was recovering as I worked out. Instead of a drop in energy I made a joke about feeling like the Energizer Bunny. 

Read on to understand how this was possible…

Abstract: The Journal of the Federation of American Societies for Experimental Biology (FASEB)

Previous research with ASEA (a saline beverage with stable superoxide complexes) found increased fatty acid mobilization in cyclists after 7 d ingestion. We hypothesized that run time to exhaustion would be favorably influenced by ASEA intake due to enhanced fatty acid oxidation and muscle glycogen sparing. Sixty mice were randomized to 1 of 4 treatment groups (n=15 each): placebo sedentary (PS), ASEA sedentary (AS), placebo run (PR), and ASEA run (AR). Mice were gavaged daily with ASEA or placebo (0.3 ml/d) for 7 d. PR and AR groups were run to exhaustion (24 m/min) at the end of the 7-d gavage period, with AR running significantly longer than PR (68.0±9.2 vs. 52.8±7.4 min, respectively) (p<0.001). At the point of exhaustion, liver glycogen was undetectable for both AR and PR. When adjusted to run time, the estimated rate of muscle glycogen depletion was different between AR and PR (0.036±0.014 and 0.052±0.018 ug/mg protein per min, respectively, p=0.017). Skeletal muscle phosphorylated acetyl-CoA carboxylase (p-ACC) was significantly increased in AR compared to AS (p=0.020) and PR (p=0.045). Fatty acyl CoA transport (CPT1), and beta-oxidation (beta-HAD) were not different between AR and PR. ASEA increased run time to exhaustion by 29% in mice, potentially through less inhibition of fatty acid oxidation via increased P-ACC, and muscle glycogen sparing percent (30%).

Physiology – Exercise, Nutrition, Growth and Tissue, Bone and Muscle Protein Synthesis:

Amy M Knab, David C Nieman, R. Andrew Shanely, Jennifer J Zwetsloot, Lynn Cialdella-Kam, and Mary Pat Meaney. Effects of ASEA beverage intake on endurance performance in mice. FASEB J April 2013 27:713.1. Source:

The FASEB Journal is among the world’s most cited biology journals. It is a preferred venue for the latest research reports and reviews of epigenetics, iRNA mechanics, histone acetylation, nitric oxide signaling, eicosanoid biochemistry, angiogenesis, tumor suppressor genes, apoptosis, cytoskeletal function, and human stem cell research. The journal publishes peer-reviewed, multidisciplinary original research articles, as well as editorials, reviews, and news of the life sciences. Vist:

Leave a Reply